Biological-risk reporting is fragmented across the International Health Regulations, the Biological Weapons Convention, and UN Security Council Resolution 1540, which can obscure situational awareness, increase administrative burden, and delay coordinated action during outbreaks. The report inductively coded 668 reporting items from IHR tools, BWC confidence-building measures, and UNSCR 1540 matrices and consolidated them into the Framework for Unified Security against Epidemics (FUSE) with 47 indicators across seven domains. About two-thirds of the harmonised indicators appear in multiple regimes, but only a small subset reflects redundant reporting, mainly in legislation, biosafety oversight, and transfer controls. The report recommends national coordination units, light-touch interoperability between secretariats, donor alignment around shared indicators, investment in tools and capacity, and pilots of integrated reporting models.