In December 2025, the U.S. Food and Drug Administration (FDA) began a significant review examining deaths potentially connected to Covid-19 vaccines, covering multiple age groups. This move follows damaging leaks of an internal FDA memo that attributed at least 10 infant deaths to Covid vaccines, though it provided no evidence. The investigation expanded from its original focus on child deaths amid controversies fueled by vaccine skepticism promoted by Health Secretary Robert F. Kennedy Jr., who was appointed by the Trump administration. The medical community has reacted with concern, emphasizing that globally, the efficacy and safety of Covid vaccines have been extensively studied and validated, and that rare severe side effects do not outweigh the benefits. The spokesperson for the Health and Human Services Department declined to provide specifics on the investigative methods, data, or timeline for completion. Kennedy's previous public statements have included unsubstantiated claims about Covid vaccines and ethnic targeting, escalating apprehension about misinformation impacting public health. This inquiry represents a major shift in U.S. vaccine policy under new leadership and presents implications for public confidence in vaccination programs during the ongoing management of the Covid-19 pandemic.